Biofilm compared to conventional antimicrobial susceptibility for Stenotrophomonas
نویسندگان
چکیده
25 Stenotrophomonas maltophilia is a multi-drug resistant organism increasingly isolated from the 26 lungs of cystic fibrosis (CF) patients. One hundred twenty-five S. maltophilia isolates from 85 27 CF patients underwent planktonic and biofilm susceptibility testing against 9 different 28 antibiotics, alone and in double antibiotics combinations. When S. maltophilia were grown as a 29 biofilm, 4 of the 10 most effective antibiotic combinations included high-dose levofloxacin and 7 30 of the 10 combinations included colistin at doses achievable by aerosolization. 31
منابع مشابه
MacABCsm, an ABC-type tripartite efflux pump of Stenotrophomonas maltophilia involved in drug resistance, oxidative and envelope stress tolerances and biofilm formation.
OBJECTIVES To characterize a five gene cluster, macRS-macABCsm, in Stenotrophomonas maltophilia. METHODS The presence of macABCsm operon was verified by RT-PCR. The substrate spectrum of the MacABCsm efflux pump was investigated by mutant construction and susceptibility testing. The physiological role of MacABCsm was assessed by comparing the growth of wild-type and macABCsm mutant under diff...
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Introduction: Stenotrophomonas maltophilia is a nosocomial multi drug resistant opportunistic pathogen which causes infections in vulnerable patients with cancer, cystic fibrosis and indwelling catheters. Methods: 45 clinical S. maltophilia isolates were collected from blood samples and identified by biochemical tests. Susceptibility to different antibiotics including co-trimoxazole, levofloxac...
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